Improving CAR-T Cell Efficacy and Persistence through ICOS and 4-1BB

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Every now and then, New Scientist helps a carefully selected commercial partner speak to our audience. Their support helps us produce the high quality journalism we bring you every week. We hope you find today's message relevant and useful.   Sino Biological Featured Products Featured Cytokines CRO Services The third and fourth generations of CAR-T cells with ICOS/CD278 and 4-1BB/CD137 intracellular domains are more efficacious and persistent in their anti-tumor activity. The dual anti-CD19/CD20 CAR-T cells with these intracellular domains exhibit prolonged and enhanced cytokine generation. Co-expression of cytokines, like IL-2, IL-7, IL-12, IL-15, and IL-18, further improves the proliferation and survival of CAR-T cells. ICOS-BBz (ICOS+4-1BB) based CARs are promising therapeutics for testing in clinical trials. Sino Biological offers quality products for these co-stimulatory molecules and these related cytokines to support the research and development of CAR-T cells.   Featured Recombinant ICOS and 4-1BB Proteins Sino Biological has a panel of verified and highly-cited recombinant ICOS, 4-1BB, and related proteins (e.g., ICOSL and CD137L/TNFSF9) to support CAR-T cell and cancer immunotherapy research.   High-purity HPLC Verified Activity Validated   High Lot-to-lot Consistency Low-endotoxin Cited by Researchers   Human ICOS Protein (Cat#: 10344-H31H) Human ICOS Ligand Protein (Cat#: 11559-H08H-B) Immobilized human ICOS ligand (Cat#: 11559-H08H) can bind human ICOS protein Immobilized human ICOS (Cat#: 10344-H03H) can bind human ICOS ligand protein Learn More ! Learn More ! Human 4-1BB/CD137 Protein (Cat#: 10041-H08H) Human 4-1BB Ligand/CD137L Protein (Cat#: 15693-H42H-B) Immobilized human 4-1BB can bind human 4-1BBL (Cat#: 15693-H01H) Ability to induce IL-8 secretion by HT1080 transfected with human CD137 Learn More ! Learn More ! More Related Targets PD1   PD-L1   OX40   CD28   TGF-beta   FAS/CD95   TNFR1   RANKL   IFN-g   CSF   BMP2   DCR3   BMP4   GDF   ACVR1   ACVR2A Sino Biological, Inc. (China) order@sinobiological.com Sino Biological US Inc. (U.S.A.) order_us@sinobiologicalus.com Sino Biological Europe GmbH (Europe) order_eu@sinobiologicaleu.com 株式会社日本シノバイオロジカル (Japan) order@sinobiological.co.jp Update preferences  |  Help  |  Contact us View in browser This email has been sent to submitpostforlive@gmail.com.   Unsubscribe from further emails relating to selected third party partners from New Scientist. Do not reply directly to this email. If you have an enquiry, please contact us using the relevant contact details listed here. Copyright © New Scientist Ltd Registered Office: Northcliffe House, 2 Derry Street, London, W8 5TT Registered in England. No.10644366 Australian mailing address: PO Box 2315, Strawberry Hills, NSW 2012, Australia Registered in Australia. ABN 22 621 413 170   Privacy Policy  |  Terms & Conditions