IL-18: A Pleiotropic Pro-Inflammatory Cytokine  | | |  | | Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine. It belongs to the IL-1 superfamily and participates in innate and acquired immunity. Recent studies have implicated the IL-18 pathway in autoimmune diseases, metabolic disorders, and cancers. | | IL-18 mediates host immunity by regulating IFN-γ production in synergy with IL-12. In the presence of IL-2, IL-18 stimulates natural killer (NK) cells, NKT cells, and established Th1 cells to produce IL-3, IL-9, and IL-13. IL-18 similarly activates downstream signal transduction as IL-1β. IL18 binds with its receptor IL-18 receptor α (IL-18Rα) . IL-18Rβ / IL-18RAcP is subsequently recruited to the complex, and the downstream cellular signal is initiated. IL-18 signaling is negatively regulated by the secreted antagonist receptor IL-18BP. IL-18Rα may also bind IL-37 in association with SIGIRR to transduce an anti-inflammatory signal. | | Sino Biological has developed a panel of recombinant IL-18 and IL-18 receptor protein reagents to support the study of the biology of IL-18. | | | | Recombinant IL-18 Cytokines and Receptors | | Sino Biological has produced high-quality recombinant IL-18 and receptor proteins from various species, such as human, mouse, cynomolgus, rhesus, rat, and canine. | | • Featured IL-18 Protein | | Human IL-18 Protein: 10119-HNCE | | | | High-purity | | Low-endotoxin | | | | Tag-free | | HPLC-verified | |  | | > 95 % as determined by SEC-HPLC | | |  |  | | Ability to induce IFN-gamma secretion by KG‑1 human acute myelogenous leukemia cells in the presence of TNF-alpha | Batch-to-batch Consistency | | | • Featured IL-18 Receptor Proteins | | | • More Related Proteins | | | | | | Antibodies for IL-18 Cytokines and Receptors | | Sino Biological has developed a panel of antibodies targeting IL-18 cytokines and receptors that can be used in ELISA, WB, IF, IP, FCM, and ICC. | | | • More Related Antibodies | | | | | |
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