IL-13 Receptors: Therapeutic Targets for Inflammatory Diseases and Cancer

Every now and then, New Scientist helps a carefully selected commercial partner speak to our audience. Their support helps us produce the high quality journalism we bring you every week. We hope you find today's message relevant and useful.   Sino Biological Featured Products Featured Cytokines CRO Services IL-13 receptors, including IL13RA1, IL13RA2, and IL4R subunits, are components of the IL-4/ IL-13 signaling pathways. They are associated with the pathogenesis and therapeutic development of cancer, asthma, and allergic diseases. As a glioma-restricted cell-surface epitope, IL13RA2 is being evaluated clinically as a potential cancer vaccine and CAR-T therapy target. The IL-13 receptors can be functionally classified into two types: shared and private. The shared IL-13 receptor is comprised of IL13RA1 and IL4R. IL-13 can also bind to the private IL-13 receptor, IL13RA2. IL13RA1 serves as the primary IL13-binding subunit of the IL-13 receptors. IL13RA2 can block IL-13-induced STAT6 signaling by acting as a decoy receptor with higher affinity. Overexpression of IL-13RA2, induced by TNF-alpha and IL-13 signaling, can contribute to pro-fibrotic effects by activating AP-1 signaling and the production of TGF beta. IL-4R can also complex with the common gamma chain ( γc/IL2RG) to mediate the signaling of IL-4.   Sino Biological has developed an array of high-quality Proteins, Antibodies, Genes, Lysate, and qPCR Primer pairs to support the study of IL-13 Receptors in understanding the immune response against neoplastic and inflammatory diseases. • From various species such as Human, Mouse, Canine, Rat, and Cynomolgus • High activity, High purity • Validated in Neutralization ELISA, WB, IF, and ICC • Rabbit MAb & PAb, Mouse MAb     Featured IL-13 Receptor Proteins Cynomolgus IL13RA1 Protein | 90864-C08H Immobilized Human IL-13 Protein (Cat#: 10369-H01H) can bind Cynomolgus IL13RA1 Protein Cynomolgus IL4R Protein | 90897-C02H Ability to inhibit IL-4 dependent proliferation of TF-1 human erthroleukemic cells Mouse IL13RA2 Protein | 50061-M38H Immobilized mouse IL13RA2 can bind IL13/Biotin (Cat#: 10369-HNAC)     Ability to inhibit mouse IL13-dependent proliferation of TF-1 human erythroleukemic cells     U.S.A Sino Biological US Inc. order_us@sinobiologicalus.com Europe Sino Biological Europe GmbH order_eu@sinobiologicaleu.com Global Sino Biological, Inc. order@sinobiological.com * This email has been sent to submitpostforlive@gmail.com * Unsubscribe from further emails relating to selected third party partners from New Scientist. * Read our privacy policy Contact Us   Disclaimer This message is intended only for the use of the person(s) ("Intended Recipient") to whom it is addressed. It may contain information which is privileged and confidential. Accordingly any dissemination, distribution, copying or other use of this message or any of its content by any person other than the Intended Recipient may constitute a breach of civil or criminal law and is strictly prohibited. If you are not the Intended Recipient, please contact the sender as soon as possible.   We and our third party service providers may use cookies and other web technologies in conjunction with this email. These technologies are used to understand activity with this email and on certain portions of our website. This enables us to improve our site, your experience on our site, and the offerings that we may provide to you. If you do not want these technologies placed on your device, please opt-out of receiving emails from us. Copyright New Scientist Registered Office: New Scientist, Northcliffe House, 2 Derry Street, Kensington, London, W8 5TT Registered in England under Company No. 10644366 Australian mailing address: PO Box 2315, Strawberry Hills, NSW 2012, Australia Registered in Australia under ABN 22 621 413 170