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November 14, 2025—Ancient dogs had surprising physical diversity, gene editing could solve rare disorders, and a test of NASA's new vision. —Andrea Gawrylewski, Chief Newsletter Editor | | NASA's ESCAPADE mission launched atop a Blue Origin New Glenn rocket from Cape Canaveral Space Force Station in Florida. Blue Origin | | Researchers analyzed hundreds of dog and wolf skulls that spanned the past 50,000 years. The oldest skull with definitive dog traits (not wolf) was nearly 11,000 years old, which aligned with previous genetic estimates of when dogs evolved from wolves. But the team also found a substantial degree of diversity in the sizes and shapes of dog skulls among the oldest samples they studied. In fact, these samples showed fully half the diversity of modern dogs—a lot more than expected.
What this means: For a long time, evolutionary biologists believed that humans were the sole driver of dog evolution as we selected for certain physical and personality traits in our dog companions. But the new results suggest that diversity in dogs' appearances arose independently. Nonhuman factors, perhaps climate or geography, may have influenced the diverse array of features. Origins of a relationship: Some experts have proposed that even the tale of humans domesticating dogs may be a bit overstated. The first dogs (which were very wolf-like) may have joined up with humans on their own, following human encampments to scavenge discarded food or the remnants of big game. | | Last year, researchers banded together to develop a personalized gene-editing therapy for a baby with a rare genetic disorder. Now, doctors are preparing to launch a groundbreaking clinical trial to do it again in more patients with similar rare disorders. The doctors plan to study base editing—which allows scientists for precise, single-letter changes to DNA sequences—in kids with genetic mutations that impact their ability to process ammonia.
How it will work: The doctors will deploy a similar array of DNA base-editing components, including the base editor used to treat the first baby. A snippet of so-called guide RNA, which directs the base editor to the DNA, will be tailored to match each child's specific mutation. Safety data from the first baby's treatment will help the researchers to optimize the process, hopefully shortening the treatment time from six months to only about three or four. What the experts say: "Personalized treatments are definitely the direction we need to steer towards," says Ryan Maple, executive director of the Global Foundation for Peroxisomal Disorders in Tulsa, Oklahoma. "This technology could be more than a game-changer. It could be revolutionary" for rare genetic disorders. —Andrea Tamayo, Newsletter Writer
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| | - Megan Averill snapped this dreamy aurora photo on her iPhone from her parents' front yard in Elk River, Minn., on Tuesday night. Thanks for sharing, Megan!
| | It's been fun to be on "aurora watch" this week at Scientific American. That active region on the sun just keeps on giving. The solar storm earlier this week was one of the most powerful of 2025. But it's not all fun and pretty pics. Solar flares send out all sorts of electromagnetic radiation, and strong bursts of X-rays and U.V. in the upper regions of our atmosphere knocked out radio signals across Europe and Africa this week, Space.com reported. | | —Andrea Gawrylewski, Chief Newsletter Editor
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