The patent clerk, with his theory of relativity, united space and time into a single, malleable substance — space-time. In doing so, he transformed the inert nothingness behind the world into a dynamic fabric of the world, one with folds that we experience as the force of gravity.
Now it's Einstein's fabric that needs unraveling. A belief has come to dominate theoretical physics that even nothingness ought to come from something — that space-time must break up into more primitive building blocks that don't themselves inhabit space or time.